BARD1 ASSOCIATED CANCER RISKS

 BREASTOVARIANGASTRICCOLORECTALPANCREATICMELANOMAPROSTATEENDOMETRIALOTHER

Additional Information

BARD1 gene

Associated Syndrome Name: BARD1-associated Cancer Risk (Women only)

BARD1 Summary Cancer Risk Table

Cancer Genetic Cancer Risk
Female BreastHigh Risk

BARD1 gene Overview

BARD1-associated Cancer Risk (Women only) 1, 2, 3
  • Women with BARD1 mutations have a risk for breast cancer that is significantly increased over the 12.5% risk for women in the general population of the United States. Most studies have found that the risk is approximately doubled, with some studies suggesting that the risk could be much higher in certain populations or in women with a family history of breast cancer.
  • At this time, there are no known cancer risks for men due to mutations in BARD1.
  • There are currently no widely accepted guidelines for the medical management of women with BARD1 mutations. Medical management options based on other conditions which increase the risk of breast cancer are listed below. Since information about the cancer risks associated with BARD1 mutations is relatively new, and there is uncertainty about the best ways to reduce these risks, it may be appropriate to interpret these results in consultation with cancer genetics professionals who have expertise in this emerging area of knowledge.

BARD1 gene Cancer Risk Table

Cancer Type Age Range Cancer Risk Risk for General Population
Female BreastTo age 801, 2, 3, 420%10.2%

BARD1 Cancer Risk Management Table

The overview of medical management options provided is a summary of professional society guidelines as of the last Myriad update shown on this page. The specific reference provided (e.g., NCCN guidelines) should be consulted for more details and up-to-date information before developing a treatment plan for a particular patient.

This overview is provided for informational purposes only and does not constitute a recommendation. While the medical society guidelines summarized herein provide important and useful information, medical management decisions for any particular patient should be made in consultation between that patient and his or her healthcare provider and may differ from society guidelines based on a complete understanding of the patient’s personal medical history, surgeries and other treatments.

Cancer Type Procedure Age to Begin Frequency
(Unless otherwise indicated by findings)
Female BreastCurrently there are no specific medical management guidelines for breast cancer risk in mutation carriers. However, the increased risk for breast cancer warrants consideration of individualized breast cancer risk-reduction strategies, such as the modification of standard population screening recommendations by starting screening at younger ages, performing screenings at greater frequency, and utilizing more sensitive technologies such as breast MRI.5, 6IndividualizedNA

Information for Family Members

The following information for Family Members will appear as part of the MMT for a patient found to have a mutation in the BARD1 gene.

A major potential benefit of myRisk genetic testing for hereditary cancer risk is the opportunity to prevent cancer in relatives of patients in whom clinically significant mutations are identified. Healthcare providers have an important role in making sure that patients with clinically significant mutations are informed about the risks to relatives, and ways in which genetic testing can guide lifesaving interventions.

At this time, there are no known cancer risks for men due to mutations in BARD1.

References

  1. Suszynska M, et al. BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation. Cancers (Basel). 2019 28 PMID: 31142030.
  2. Weber-Lassalle N, et al. Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer. Breast Cancer Res. 2019 21:55. PMID: 31036035.
  3. Cancer.Net, American Society of Clinical Oncology, Melanoma: Risk Factors and Prevention 2019 Available at http://www.cancer.net/cancer-types/melanoma/risk-factors-and-prevention.
  4. Fast Stats: An interactive tool for access to SEER cancer statistics. Surveillance Research Program, National Cancer Institute. https://seer.cancer.gov/faststats. (Accessed on 1-2-2017)
  5. Bevers TB, et al. NCCN Clinical Practice Guidelines in Oncology®: Breast Cancer Screening and Diagnosis. V 1.2019. May 17. Available at http://www.nccn.org.
  6. Daly M et al. NCCN Clinical Practice Guidelines in Oncology®: Genetic/Familial High-Risk Assessment: Breast, Ovarian and Pancreatic. V 1.2020. Dec 4. Available at http://www.nccn.org.
Last Updated on 25-Feb-2020