- Hereditary Breast and Ovarian Cancer syndrome (HBOC)
- Lynch syndrome/Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
- Familial Adenomatous Polyposis (FAP)/Attenuated Familial Adenomatous Polyposis (AFAP)
- MUTYH-associated Polyposis syndrome (MAP)
- MUTYH-associated Colon Cancer Risk
- Melanoma Cancer Syndrome (MCS)
- Li-Fraumeni Syndrome (LFS)
- PTEN Hamartoma Tumor syndrome (PHTS)
- Peutz-Jeghers Syndrome
- Hereditary Diffuse Gastric Cancer (HDGC) Syndrome
- Juvenile Polyposis Syndrome (JPS)
- Juvenile Polyposis Syndrome (JPS) and Hereditary Hemorrhagic Telangiectasia (HHT)
- PALB2-associated Cancer Risk
- CHEK2-associated Cancer Risk
- ATM-associated Cancer Risk
- NBN-associated Cancer Risk
- BARD1-associated Cancer Risk
- BRIP1-associated Cancer Risk
- RAD51C-associated Cancer Risk
- RAD51D-associated Cancer Risk
- Polymerase Proofreading-associated Syndrome (PPAS)
- Hereditary Mixed Polyposis Syndrome (HMPS)
Juvenile Polyposis Syndrome (JPS) BMPR1A ASSOCIATED CANCER RISKS
Juvenile Polyposis Syndrome (JPS)
BMPR1A ASSOCIATED CANCER RISKS
What does it mean to have a diagnosis of Juvenile Polyposis Syndrome?
Juvenile Polyposis Syndrome (JPS) is caused by mutations in one of two genes: BMPR1A and SMAD4. People with JPS have growths in their digestive system that can lead to cancer. These growths are called “juvenile polyps” and can develop in adults as well as in children. The most common locations for juvenile polyps are the colon, rectum, stomach and small intestine. The juvenile polyps can cause problems by bleeding and/or blocking the intestines.
People with JPS have an increased risk for cancers of the colon, rectum, and stomach. There are also slightly elevated risks for small bowel and pancreatic cancers.
What can be done to protect people with JPS from cancer?
The National Comprehensive Cancer Network (NCCN) provides recommendations for lowering the risk of cancer and other health problems in men and women with JPS. These recommendations include starting screening of the stomach and intestines at young ages and having the screenings frequently. For example, colonoscopies to check for juvenile polyps in the colon should begin at age 15 or younger and should be done every few years. People with JPS should also be checked for anemia, which could be caused by bleeding from juvenile polyps.
JPS is a relatively rare condition, so it is recommended that people with JPS be cared for by healthcare professionals with experience in treating this condition.
Additional details about JPS, including information about the risks for different kinds of cancer, specific recommendations for medical care, and useful information for relatives of people who have a diagnosis of JPS, are available within our Support Organizations pages.
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