- Hereditary Breast and Ovarian Cancer syndrome (HBOC)
- Lynch syndrome/Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
- Familial Adenomatous Polyposis (FAP)/Attenuated Familial Adenomatous Polyposis (AFAP)
- MUTYH-associated Polyposis syndrome (MAP)
- MUTYH-associated Colon Cancer Risk
- Melanoma Cancer Syndrome (MCS)
- Li-Fraumeni Syndrome (LFS)
- PTEN Hamartoma Tumor syndrome (PHTS)
- Peutz-Jeghers Syndrome
- Hereditary Diffuse Gastric Cancer (HDGC) Syndrome
- Juvenile Polyposis Syndrome (JPS)
- Juvenile Polyposis Syndrome (JPS) and Hereditary Hemorrhagic Telangiectasia (HHT)
- PALB2-associated Cancer Risk
- CHEK2-associated Cancer Risk
- ATM-associated Cancer Risk
- NBN-associated Cancer Risk
- BARD1-associated Cancer Risk
- BRIP1-associated Cancer Risk
- RAD51C-associated Cancer Risk
- RAD51D-associated Cancer Risk
- Polymerase Proofreading-associated Syndrome (PPAS)
- Hereditary Mixed Polyposis Syndrome (HMPS)
RAD51D ASSOCIATED CANCER RISKS
RAD51D ASSOCIATED CANCER RISKS
What does it mean to have a RAD51D gene mutation?
Women with mutations in the RAD51D gene have an increased risk for ovarian cancer. Researchers have only recently learned about cancer risk associated with RAD51D, and the exact size of the risk is unknown. However, the risk associated with RAD51Dmutations could be as much as 4 times higher than the risk for women who do not have a mutation in this gene.
At this time, we do not know of any cancer risks for men with RAD51D mutations.
What can be done to protect women with RAD51D mutations from cancer?
At this time, there are no standard recommendations for lowering the risk of ovarian cancer in women with mutations in RAD51D. However, women with mutations in RAD51D can talk with their doctors and other healthcare providers about possible individualized recommendations such as special screening or preventative surgeries.
Associated Syndrome Name: RAD51D-associated Cancer Risk (Women only)
RAD51D Summary Cancer Risk Table
|Cancer||Genetic Cancer Risk|
RAD51D gene Overview
RAD51D-associated Cancer Risk (Women only) 1, 2, 3, 4
- Women with RAD51D mutations have an increased risk for ovarian cancer.
- At this time, there are no known cancer risks for men due to mutations in RAD51D.
- Although there are high cancer risks for patients with mutations in RAD51D, there are interventions that may be effective at reducing these risks. Guidelines from the National Comprehensive Cancer Network (NCCN) that may apply are listed below. Since information about the cancer risks associated with RAD51D mutations is relatively new, and there is still some uncertainty about the best ways to reduce these risks, it may be appropriate to interpret these results in consultation with cancer genetics experts in this emerging area of knowledge.
RAD51D gene Cancer Risk Table
|Cancer Type||Age Range||Cancer Risk||Risk for General Population 5|
|Ovarian||To age 504||2.3%||0.2%|
|To age 801, 4||14.8%||1.0%|
RAD51D Cancer Risk Management Table
The overview of medical management options provided is a summary of professional society guidelines as of the last Myriad update shown on this page. The specific reference provided (e.g., NCCN guidelines) should be consulted for more details and up-to-date information before developing a treatment plan for a particular patient.
This overview is provided for informational purposes only and does not constitute a recommendation. While the medical society guidelines summarized herein provide important and useful information, medical management decisions for any particular patient should be made in consultation between that patient and his or her healthcare provider and may differ from society guidelines based on a complete understanding of the patient’s personal medical history, surgeries and other treatments.
|Cancer Type||Procedure||Age to Begin||Frequency |
(Unless otherwise indicated by findings)
|Ovarian||Consider bilateral salpingo-oophorectomy (BSO).6||45 to 50 years, or earlier if there is a family history of ovarian cancer at a younger age||NA|
|Other than consideration of BSO, currently there are no specific medical management recommendations for ovarian cancer risk in mutation carriers. However, the increase in risk may warrant consideration of individualized ovarian cancer risk-reduction strategies using other currently available options, such as surveillance and the use of risk-reducing agents.6||Individualized||NA|
Information for Family Members
The following information for Family Members will appear as part of the MMT for a patient found to have a mutation in the RAD51D gene.
A major potential benefit of myRisk genetic testing for hereditary cancer risk is the opportunity to prevent cancer in relatives of patients in whom clinically significant mutations are identified. Healthcare providers have an important role in making sure that patients with clinically significant mutations are informed about the risks to relatives, and ways in which genetic testing can guide lifesaving interventions.
At this time, there are no known cancer risks for men due to mutations in RAD51D.
- Loveday C, et al. Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat Genet. 2011 43:879-82. PMID: 21822267.
- Thompson ER, et al. Analysis of RAD51D in Ovarian Cancer Patients and Families with a History of Ovarian or Breast Cancer. PLoS One. 2013 8:e54772. PMID: 23372765.
- Wickramanyake A, et al. Loss of function germline mutations in RAD51D in women with ovarian carcinoma. Gynecol Oncol. 2012 127:552-5. PMID: 22986143.
- Song H, et al. Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. J Clin Oncol. 2015 10:2901-7. PMID: 26261251.
- Fast Stats: An interactive tool for access to SEER cancer statistics. Surveillance Research Program, National Cancer Institute. https://seer.cancer.gov/faststats. (Accessed on 1-2-2017)
- Daly M et al. NCCN Clinical Practice Guidelines in Oncology®: Genetic/Familial High-Risk Assessment: Breast and Ovarian. V 2.2019. July 30. Available at http://www.nccn.org.
Last Updated on 07-Nov-2018