Understanding Negative Results
The Value of knowing
Regardless of the results, you and your healthcare provider will benefit from the knowledge and insight the test provides. Knowing whether you are positive (you have a broken gene) or negative (you do not) enables you and your healthcare provider to create a personal health management plan.
A negative result on the Myriad myRiskâ„˘ Hereditary CancerÂ panelÂ means that there were no mutations detected in your genetic makeup related to hereditary cancer. Because of this, your risk for a hereditary cancer is lower but not completely ruled out.
It is not uncommon for cancer to â€śrun in the familyâ€ť when there is no genetic evidence of hereditary cancer. If this is the case for you, you might still have a higher risk than the general population. Your healthcare provider may want you to have screening tests more often so you can be monitored more closely. It is also important that you share your test status with your family so that they can follow up with their own healthcare providers to determine their risk.
Risks: A personal and/or family cancer history may be a sign of increased cancer risk. You were likely tested because of personal or family history of cancers. Even though you do not have a gene mutation, your risk is not likely the same as individuals without a similar cancer history.
Your risk could be increased due to
- Your concerning personal and/or family history
- Other nonhereditary factors (for example, your environment or lifestyle)
- Another hereditary cancer syndrome
- A mutation that this testing does not detect
Management: If sufficient personal and family history was provided for analysis, your report may prompt â€śmodified medical managementâ€ť and this section will highlight changes management recommendations made by leading medical societies that you and your healthcare provider may want to consider. The two of you will work together to determine the best management plan for you.
Family: Family members should consider talking to their healthcare providers about hereditary cancer testing to help define their own hereditary cancer risk. While your test report may be helpful for your familyâ€™s hereditary cancer assessment, each individualâ€™s genetic makeup is different and may still require individual testing.
â€śVariants not requiring clinical actionâ€ť: A variant is a gene with a different appearance than most genes of the same type. Variants are common and usually harmless. If a variant has no known associated clinical actions, or is not associated with hereditary cancer risk, it is not reported. Myriad has made a major commitment to understanding the nature of unknown variants. If Myriad identifies new information about a variant that makes it clinically actionable, that information will be made available.