Genetic Testing Process

There are four parts to the hereditary cancer testing process.

Consult TEST LEARN Discuss

Consult

The first step is a consultation with your healthcare professional. He or she will help you understand about hereditary cancer and the genetic testing process, and will encourage you to ask questions. The following resources can help you prepare for this important meeting:

If you do not yet have a healthcare professional who can take you through the hereditary cancer risk screening process, you can find one by using our Find a Provider tool.

Red flags checklist

This checklist can help you identify your possible risk of Hereditary Breast and Ovarian Cancer (HBOC) syndrome and Lynch syndrome. You can print the results and bring them with you to your consultation with your healthcare professional.

Consider both your mother’s and father’s sides of the family when answering the following questions to help in assessing your hereditary cancer risk factors for breast and ovarian cancer.

Do you have a family or personal history of any of the following?

  • Breast cancer before age 50?
  • Ovarian cancer at any age?
  • Two primary breast cancers in the same individual at any age or on the same side of the family?
  • Male breast cancer at any age?
  • Three or more breast cancers in a family at any age?
  • Ashkenazi Jewish ancestry with breast cancer at any age?
  • A previously identified BRCA mutation in the family?
  • Triple negative breast cancer?
  • Pancreatic cancer with an additional HBOC-associated* cancer

*+ HBOC-associated cancers includes breast (including DCIS), ovarian, pancreatic, and aggressive prostate cancer

  • You or a close family member^ were diagnosed with colon, rectal, or endometrial cancer before age 50
  • You or a family member were diagnosed with two or more Lynch syndrome cancers± at any age in the same person
  • Two or more family members were diagnosed with a Lynch syndrome cancer± on the same side of the family, one before age 50
  • There are three or more family members with a Lynch syndrome cancer± on the same side of the family at any age

There is a previously identified Lynch syndrome or MAP syndrome mutation in your family
±Lynch syndrome-associated cancers include colon/rectal, endometrial, ovarian, stomach/gastric, kidney/urinary tract, biliary tract, small bowel, pancreas, brain, and sebaceous adenoma cancers.^Close family members are parents, siblings, aunts, uncles, nieces, nephews, grandparents and grandchildren.

Learn more about your individual risks by taking our self-assessment quiz.

Assessment criteria are based on medical society guidelines. Go to www.myriadpro.com to learn more about these individual guidelines.

Take the Myriad Hereditary Cancer Quiz

Myriad Genetics’ Hereditary Cancer Quiz helps you to assess whether you might be a good candidate for testing. This quiz can help you get the information you need to discuss your risk of cancer with your healthcare provider and ask for further evaluation. If you take the quiz and find red flags in your own history or your family history, you may benefit from hereditary cancer testing.

The quiz will help you determine if you are at risk for the following hereditary cancers:

  • Breast
  • Ovarian
  • Colon
  • Endometrial
  • Pancreatic
Start the Quiz

Test

The information gained from testing gives you and your family members the best chance at reducing your risk of future cancers. If you and your doctor decide that you are a candidate for genetic testing, there are many options available from Myriad Genetic Laboratories.

myRisk™

Myriad myRisk hereditary cancer panel combines your genetic information with the personal and family history you give your provider to determine your hereditary cancer risk.

Evaluates clinically actionable gene mutations associated with a focus on eight cancer sites

Blends genetic test status AND personal/family cancer history into clinically actionable risk assessment and follow-up

BRAC Analysis®: a test for Hereditary Breast & Ovarian Cancer syndrome (HBOC)
  • Integrated BRACAnalysis
    This test is used if no one else in your family has been tested, or no one else has had a positive result for a gene mutation. It checks for mutations in the BRCA1 and BRCA2 genes associated with HBOC syndrome.
  • Single Site BRACAnalysis
    When a gene mutation has been previously identified in another family member, this screening test will look for that specific mutation only.
  • Multisite 3 BRACAnalysis
    This BRACAnalysis test is used for the three most common mutations found in people of Ashkenazi, or Eastern European, Jewish ancestry.
  • BRACAnalysis Large Rearrangement Test (BART)
    Most BRCA1 and BRCA2 gene mutations can be found with the standard BRACAnalysis test. However, there are some less common gene mutations that can only be found using a test called the BRACAnalysis Large Rearrangement Test (BART).
COLARIS®: a test for Hereditary Colon Cancer
  • COLARISPLUS
    This test is used if no one else in your family has been tested or no one else has had a positive result for a gene mutation. It checks for gene mutations in the following genes: MLH1, MSH2, MSH6, PMS2,EPCAM, and MYH.
  • COLARIS AP®PLUS
    This test aids assessment of the risk of developing hereditary colorectal polyps; it detects mutations in the APC and MYH genes, which cause adenomatous polyposis colon cancer syndromes.
  • Single Site COLARIS or Single Site COLARIS AP
    This test is used if there is a known gene mutation in your family so your healthcare professional can look for a specific mutation.
  • Gene-Specific COLARIS
    This test is appropriate for individuals with cancer who have had tumor analysis indicating they might have Lynch syndrome.
MELARIS®: a test for hereditary melanoma

This test detects inherited mutations in the p16 gene (also called CDKN2A or INK4A), which are associated with hereditary melanoma.

Unique tests to aid cancer treatment planning

Additional testing is also available to help those who have already been diagnosed with cancer. A doctor might order one of these tests to learn more about tumor behavior or an individual patient’s possible response to therapy. The results of these tests help to make personalized treatment possible.

PROLARIS®: a test to assess prostate cancer aggressiveness

This test measures the expression levels of the genes involved in cell cycle progression. At the time of diagnosis, Prolaris can help to identify patients with less aggressive cancer who may be candidates for active surveillance. In addition, Prolaris can identify patients who appear clinically low-risk but have a more aggressive disease that requires more aggressive treatment. Visit Prolaris.com to learn more about this unique test.

Myriad Genetics’ Hereditary Cancer Quiz helps you to assess whether you might be a good candidate for testing.

Learn

The results of your test will be sent to your healthcare provider within about two to three weeks. He or she will meet with you to explain what the test found. Your results may be more than simply “positive” or “negative.”

myRisk

myRisk™

Myriad myRisk hereditary cancer panel combines your genetic information with the personal and family history you give your provider to determine your hereditary cancer risk.

Evaluates clinically actionable gene mutations associated with a focus on eight cancer sites

Blends genetic test status AND personal/family cancer history into clinically actionable risk assessment and follow-up

BRAC Analysis®
  • Integrated BRACAnalysis
  • BRACAnalysis Large Rearrangement Test
  • Single Site BRACAnalysis
  • Multisite 3 BRACAnalysis
COLARIS®
  • COLARISPLUS
  • COLARIS APPLUS
  • Single Site COLARIS
  • Gene Specific COLARIS
MELARIS®

MELARIS® testing assesses a person’s risk of developing hereditary melanoma by detecting inherited mutations in the p16 gene (also called CDKN2A or INK4A), which is associated with hereditary melanoma and pancreatic cancer. Changes in the p16 gene increase cancer risk, making a melanoma diagnosis up to 50 times more likely by age 50.

MELARIS® is a simple blood test that determines whether a patient has a mutation in the p16 gene. Knowing the results of the MELARIS® test may help patients and their act before cancer has had a chance to develop.

Myriad has developed a Hereditary Cancer Quiz that patients and can use to help identify potential candidates for genetic testing using MELARIS®.

If you’ve received a test that is not listed here, ask your healthcare provider for an explanation of the results. Your test results are always personal and confidential. Learn about how patient privacy is protected.

Who uses your information?

Only you and your healthcare provider will be able to see the results you receive from your test. The Health Insurance Portability and Accountability Act (HIPAA) of 1996 created federal privacy protections that apply to all health information created or maintained by healthcare providers, health plans, and healthcare clearinghouses.

In addition, HIPAA created federal security standards that apply to protected health information that is in an electronic format. State laws have also been enacted to protect patient privacy.

This means that any personal or family information you provide, and any information gained from the tests you take, cannot be shared without your permission. Learn more about patient privacy.

Myriad Genetics’ Hereditary Cancer Quiz helps you to assess whether you might be a good candidate for testing.

Discuss

If your test shows that you do carry a gene mutation that increases your risk for cancer, this is powerful information that can help both you and your family. You and your healthcare team can use the results to support plans and informed decisions about your health.

Other family members may need to be tested in order to find out if they too share the same genetic trait that can increase their cancer risk. You can help your family understand that if they get tested, the information from their results will enable them to take steps to reduce their cancer risk dramatically.

Testing can also inform family members that they are not at increased risk when they test negative for a family mutation. Just knowing that there are no known hereditary factors or hereditary syndrome that can lead to an increased risk of cancer can be of great comfort.

Talk with family members about getting tested and about how knowing more can help reduce their concern, as well as their risk. Here are some tips for starting a family discussion:

  • Start by telling your loved ones about your own journey as you learned about your hereditary cancer risks
  • Sit down with the family and show them this website
  • Encourage them to get and stay healthy by exercising, eating a diet rich in antioxidants, and quitting smoking or other poor health habits
  • Hand out printable information cards to family members to encourage them to talk with their healthcare providers about the family history

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